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BACKGROUND:The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
METHODS:By using a cross‐sectional design, patients with clinically stable (10 ± 7 days postsurgery) high‐grade glioma (HGG; n = 25) or low‐grade glioma (LGG; n = 10) were studied. Participants...
BACKGROUND:Radiotherapy is the current standard of care for patients with localized squamous cell cancer of the anal canal. The goal of the current study was to evaluate long‐term quality of life (QoL) in patients after this treatment.
METHODS:Questionnaires were mailed to 80 patients treated with definitive radiotherapy, with or without concurrent chemotherapy, for anal cancer, with a minimum 2‐year...
BACKGROUND:Adjuvant therapies for pancreatic and periampullary cancer reportedly achieve only a marginal survival benefit. In this randomized controlled trial, 120 patients with resected pancreatic or periampullary cancer received either adjuvant celiac axis infusion chemotherapy combined with radiotherapy (CAI/RT) or no adjuvant treatment. The objective of the study was to compare the quality of...
BACKGROUND:Based on Survivors' Guidance, an interactive, Web‐based, culturally relevant Native American cancer survivorship program, Native American Cancer Education for Survivors (NACES), was developed. The focus of the program is to improve quality of life (QOL) for Native American breast cancer survivors.
METHODS:NACES is a community‐driven research and education project, based on the Social Cognitive...
BACKGROUND:Androgen deficiency is increasingly recognized in young male cancer survivors; however, its impact on quality of life (QOL) is not established. The authors investigated the relationship between androgen levels, QOL, self‐esteem, fatigue, and sexual function in young male cancer survivors compared with control subjects.
METHODS:A cross‐sectional, observational study of 176 male cancer survivors...
BACKGROUND:We prospectively compared the proxy reporting of health‐related quality of life (HRQL) by parents and nurses of children with Hodgkin disease to see how well they correlated with the children's report.
METHODS:Children with all stages of Hodgkin disease, their parents, and the clinic nurse were all asked to complete 4 different HRQL measures at 4 time points: 2 weeks after the first course...
BACKGROUND:We evaluated 4 different health‐related quality of life (HRQL) measures prospectively to determine their ability to detect change over time: the Health Utilities Index Mark 2 and Mark 3, the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core and Cancer Module, the EuroQol EQ‐5D visual analogue scale (EuroQol), and the Lansky Play‐Performance Scale.
METHODS:Children with all...
BACKGROUND:Although it is known that standard 5‐fluorouracil–based chemoradiation therapy for rectal cancer causes significant acute gastrointestinal (GI) toxicity, research on patient‐reported outcomes (PROs) is limited. The authors undertook the current study to assess the feasibility of incorporating PRO measurement into routine clinical practice and to describe the trajectory of symptom development...
BACKGROUND:Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross‐sectional study of the long‐term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon.
METHODS:Seven hundred thirty‐nine patients who were treated between 1982 and 1992 gave consent to enter the study. Patients were classified...
BACKGROUND:Health‐related quality of life (HRQoL) is a key issue in patients with metastatic esophagogastric cancer, a disease associated with survival times rarely exceeding 10 months. The objective of the current review was to evaluate the effects of chemotherapy on the HRQoL of patients with metastatic or locally advanced, inoperable esophagogastric cancer.
METHODS:A systematic MEDLINE search...
BACKGROUND:The purpose of the study was to investigate the adequacy of palliative radiation treatment in end‐stage cancer patients.
METHODS:Of 216 patients referred for palliative radiotherapy, 33 died within 30 days and constitute the population of the study. Symptoms, Karnofsky Performance Status (KPS), laboratory tests, and survival estimates were obtained. Treatment course was evaluated by medical...
BACKGROUND:The devastating impact of lymphedema on cancer survivors' quality of life has prompted consideration of several changes in medical and surgical care. Unfortunately, our understanding of the benefits gained from these approaches relative to their cost remains limited. This study was designed to estimate utilities for lymphedema and characterize how utilities differ between subgroups defined...
BACKGROUND:This study investigated the agreement between self‐reports from pediatric brain tumor patients and proxy reports from their parents regarding the patients' quality of life (QOL), as assessed using a brain tumor‐specific QOL assessment tool, the Pediatric Functional Assessment of Cancer Therapy‐Childhood Brain Tumor Survivors (pedsFACT‐BrS) questionnaire. The authors expected moderate correlation...
BACKGROUND:Epidermal growth factor receptor (EGFR) inhibitors frequently result in dermatologic toxicities, including rash, xerosis, pruritus, and paronychia. Although the frequency and severity of these events have been described, their effect on health‐related quality of life (QoL) remains poorly understood. By using a dermatology‐specific questionnaire, the authors examined the effect of these...
BACKGROUND:The objective of this study was to determine whether surgery for patients with spinal metastases could improve the quality of remaining life and prolong survival.
METHODS:In total, 96 patients who had spinal metastases were recruited from Changzheng Hospital at the Second Military Medical University in Shanghai, China, over the period from July 2007 to June 2009. The patients received...
BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and prognosis, associations with symptom burden and QOL have not been examined. The current...
BACKGROUND:The objective of this study was to compare the incidence of hand‐foot syndrome (HFS) in patients who received pyridoxine versus placebo during pegylated liposomal doxorubicin (PLD) chemotherapy for recurrent ovarian, breast, or endometrial cancer.
METHODS:Patients received PLD 40 mg/m2 for a maximum of 6 cycles. Patients were assigned randomly to receive pyridoxine 100 mg twice daily (Group...
BACKGROUND:Fatigue is a highly prevalent and clinically significant symptom of advanced prostate cancer. To date, however, there are no published controlled trials of interventions for fatigue in men with prostate cancer.
METHODS:This 6‐week, randomized, double‐blind, placebo‐controlled design evaluated the efficacy of methylphenidate to treat fatigue in prostate cancer patients. Inclusion criteria...
Theories of human development suggest that, although all cancer patients experience a common set of life disruptions, they experience them differently, focus on different issues, and attach different levels of importance to different aspects of the experience depending on the time in life at which they were diagnosed. During the critical developmental transition from childhood to adulthood, older...
To deliver developmentally appropriate psychosocial care, the key developmental tasks facing adolescents and young adults (AYA) need to be taken into consideration. These include establishing autonomy from parents; a personal set of values and identity; strong peer relationships, including intimate and sexual relationships; and obtaining adequate preparation to join the workforce. To minimize the...
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